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Plexr Plus

Plexr Plus

Abstract

Plexr Plus is a patented micro-plasma device manufactured by GMV in Italy that generates controlled electric arcs through ionization of atmospheric gases.

Device Overview

Technical Specifications

Core Technology:

  • Electric breakdown: ~3000 V per mm
  • Optimal distance: 0.5mm from tissue
  • Probe tip width: 0.5mm
  • Mechanism: Sublimation (solid to gas) without heat transfer

Hardware:

  • Three wireless handpieces: White, Green, Red (calibrated for different power levels)
  • White handpiece (ophthalmology): 0.7-watt power
  • Touch display with multilingual software
  • Wireless charging base
  • Operating duration: up to 8 hours

Mechanism of Action:

  • Generates Reactive Oxygen and Nitrogen Species (RONS)
  • Stimulates Type III collagen regeneration
  • Causes controlled tissue contraction
  • No return electrode needed (unlike electrosurgery)
  • Lower power than electrosurgical units

Regulatory Status:

  • FDA cleared: skin lesion removal and tissue coagulation
  • CE certified (Europe)
  • TGA listed (Australia)
  • Health Canada licensed (first fully licensed plasma technology, 2021)
  • Distributed in 60+ countries

Clinical Evidence:

  • 40+ scientific publications
  • 12+ years clinical use
  • Millions of treatments performed worldwide

Ophthalmological Applications

PANIS Method

Plasma-Assisted Noninvasive Surgery - developed by Iranian Vision Research Center for ocular surface disorders using Plexr Plus technology.

Treatable Pathologies

1. Dermatochalasis (Non-Surgical Blepharoplasty)

  • Pathology: Drooping eyelid skin, age-related laxity
  • Plexr Plus Results: 100% improvement rate, +2.6 grade increase, immediate visible results lasting years, 30-35% improvement per session

2. Conjunctivochalasis

  • Pathology: Loose redundant conjunctiva causing tearing, irritation
  • Plexr Plus Results: Grade 3-4 reduced to grade 1-2 in 1 month, all normalized at 6 months, no recurrence, 5-10 minute procedure

3. Pterygium

  • Pathology: Fibrovascular growth onto cornea from UV exposure
  • Plexr Plus Results: Improved visual acuity, no sutures/glue needed, few minutes procedure (vs. 30 min traditional), 0-33% recurrence rates

4. Conjunctival Nevus

  • Pathology: Benign melanocytic tumor
  • Plexr Plus Results: Complete disappearance outside limbus, size reduced from 3.89×11.7mm to 0.54×1.69mm, no recurrence, no complications

5. Dry Eye (Punctal Occlusion)

  • Pathology: Aqueous deficient dry eye
  • Plexr Plus Results: TMH +79.8%, TBUT +69.99%, Schirmer +86.20%, sustained 3-6 months, no foreign body sensation vs. plugs

6. Conjunctival Cyst

  • Pathology: Fluid-filled epithelial inclusion cysts
  • Plexr Plus Results: 100% complete healing, no recurrence, no complications, no scarring

7. Chalazion

  • Pathology: Meibomian gland obstruction/inflammation
  • Plexr Plus Application: Alternative to incision/curettage for chronic cases, minimally invasive drainage

8. Entropion

  • Pathology: Inward turning eyelid causing corneal irritation
  • Plexr Plus Application: Tissue tightening for mild involutional cases, adjunct to correct malposition

9. Conjunctival Stria

  • Pathology: Linear conjunctival folds from laxity
  • Plexr Plus Application: Tissue shrinkage and remodeling to reduce striations

Key Advantages of Plexr Plus

vs. Surgery:

  • No operating room, no general anesthesia, no incisions
  • Office-based procedures
  • 1-2 day recovery vs. weeks
  • Lower cost

vs. Other Energy Devices:

  • No heat conduction to surrounding tissue
  • More precise (0.5mm tip)
  • Safer for periocular/ocular surface
  • No return electrode

Clinical Benefits:

  • Single device, multiple applications
  • Topical anesthesia only
  • 5-30 minute procedures
  • Immediate results
  • Minimal complications

Safety Profile:

  • Superficial action preserves deep structures
  • No thermal damage to underlying tissue
  • Minimal bleeding/inflammation
  • 7-14 day healing

Summary

Plexr Plus treats 9 ophthalmological pathologies:

  • 2 eyelid disorders
  • 5 conjunctival surface disorders
  • 2 functional/glandular disorders

Device uniqueness: Wireless handpieces, 0.7W white handpiece for ophthalmology, precise 0.5mm tip, no heat spread, extensive global validation (40+ publications, 60+ countries, 12+ years use).

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